| 1 | 4519 CHUGAI PHARMACEUTICAL CO., LTD. | 18.6% FY2025 | FY2025 |
| 2 | 4570 Immuno-Biological Laboratories Co., Ltd. | 16.4% FY2025 | FY2025 |
| 3 | 4595 MIZUHO MEDY CO.,LTD. | 15.9% FY2025 | FY2025 |
| 4 | 4506 Sumitomo Pharma Co., Ltd. | 13.8% FY2025 | FY2025 |
| 5 | 197A TAUNS Laboratories,Inc. | 13.5% FY2025 | FY2025 |
| 6 | 4507 Shionogi & Co., Ltd. | 10.0% FY2025 | FY2025 |
| 7 | 9273 KOA SHOJI HOLDINGS CO.,LTD. | 9.9% FY2025 | FY2025 |
| 8 | 4516 Nippon Shinyaku Co., Ltd. | 9.4% FY2025 | FY2025 |
| 9 | 4578 Otsuka Holdings Co., Ltd. | 9.2% FY2025 | FY2025 |
| 10 | 4536 SANTEN PHARMACEUTICAL CO., LTD. | 9.0% FY2025 | FY2025 |
| 11 | 4503 Astellas Pharma Inc. | 8.4% FY2025 | FY2025 |
| 12 | 4568 DAIICHI SANKYO COMPANY, LIMITED | 7.5% FY2025 | FY2025 |
| 13 | 4527 ROHTO PHARMACEUTICAL CO.,LTD. | 7.4% FY2025 | FY2025 |
| 14 | 4556 KAINOS Laboratories,Inc. | 7.4% FY2024 | FY2024 |
| 15 | 4574 TAIKO PHARMACEUTICAL CO.,LTD. | 7.3% FY2025 | FY2025 |
| 16 | 4530 HISAMITSU PHARMACEUTICAL CO.,INC. | 6.5% FY2024 | FY2024 |
| 17 | 4528 ONO PHARMACEUTICAL CO., LTD. | 6.4% FY2025 | FY2025 |
| 18 | 4151 Kyowa Kirin Co., Ltd. | 6.2% FY2025 | FY2025 |
| 19 | 4549 EIKEN CHEMICAL CO.,LTD. | 5.9% FY2025 | FY2025 |
| 20 | 4540 TSUMURA & CO. | 5.3% FY2025 | FY2025 |
| 21 | 4547 KISSEI PHARMACEUTICAL CO., LTD. | 5.3% FY2025 | FY2025 |
| 22 | 4886 ASKA Pharmaceutical Holdings Co., Ltd. | 5.0% FY2025 | FY2025 |
| 23 | 4559 ZERIA PHARMACEUTICAL CO., LTD. | 5.0% FY2025 | FY2025 |
| 24 | 4534 Mochida Pharmaceutical Co.,Ltd. | 4.6% FY2025 | FY2025 |
| 25 | 4577 Daito Pharmaceutical Co.,Ltd. | 4.2% FY2025 | FY2025 |
| 26 | 4551 TORII PHARMACEUTICAL CO., LTD. | 3.7% FY2024 | FY2024 |
| 27 | 4524 MORISHITA JINTAN CO., LTD. | 3.4% FY2025 | FY2025 |
| 28 | 4554 Fuji Pharma Co.,Ltd. | 3.3% FY2024 | FY2024 |
| 29 | 4887 SAWAI GROUP HOLDINGS Co., Ltd. | 2.9% FY2025 | FY2025 |
| 30 | 4885 MUROMACHI CHEMICALS INC. | 2.8% FY2025 | FY2025 |
| 31 | 177A Kohjin Bio Co., Ltd. | 2.8% FY2025 | FY2025 |
| 32 | 4523 Eisai Co., Ltd. | 2.7% FY2025 | FY2025 |
| 33 | 4579 RaQualia Pharma Inc. | 2.7% FY2025 | FY2025 |
| 34 | 219A Heartseed Inc. | 2.6% FY2024 (14 months) | FY2024 (14 months) |
| 35 | 4538 Fuso Pharmaceutical Industries, Ltd. | 2.3% FY2025 | FY2025 |
| 36 | 4552 JCR Pharmaceuticals Co.,Ltd. | 2.0% FY2025 | FY2025 |
| 37 | 7096 StemCell Institute Inc. | 1.9% FY2025 | FY2025 |
| 38 | 4569 KYORIN Pharmaceutical Co., Ltd. | 1.8% FY2025 | FY2025 |
| 39 | 4548 SEIKAGAKU CORPORATION | 1.7% FY2025 | FY2025 |
| 40 | 4558 CHUKYOIYAKUHIN CO.,LTD. | 1.6% FY2025 | FY2025 |
| 41 | 4512 WAKAMOTO PHARMACEUTICAL CO.,LTD. | 1.4% FY2025 | FY2025 |
| 42 | 4531 YUKI GOSEI KOGYO CO., LTD. | 1.2% FY2025 | FY2025 |
| 43 | 4521 KAKEN PHARMACEUTICAL CO., LTD. | 1.2% FY2025 | FY2025 |
| 44 | 4553 TOWA PHARMACEUTICAL CO., LTD. | 1.1% FY2025 | FY2025 |
| 45 | 4539 NIPPON CHEMIPHAR CO., LTD. | 0.4% FY2025 | FY2025 |
| 46 | 4502 Takeda Pharmaceutical Company Limited | -1.0% FY2025 | FY2025 |
| 47 | 4587 PeptiDream Inc. | -4.4% FY2025 | FY2025 |
| 48 | 2160 GNI Group Ltd. | -5.5% FY2025 | FY2025 |
| 49 | 4584 Kidswell Bio Corporation | -6.3% FY2025 | FY2025 |
| 50 | 4565 Nxera Pharma Co., Ltd. | -8.8% FY2025 | FY2025 |
| 51 | 4889 Renascience Inc. | -11.2% FY2025 | FY2025 |
| 52 | 4593 HEALIOS K.K. | -14.2% FY2025 | FY2025 |
| 53 | 4888 STELLA PHARMA CORPORATION | -15.8% FY2025 | FY2025 |
| 54 | 4893 Noile-Immune Biotech Inc. | -18.0% FY2025 | FY2025 |
| 55 | 4894 Cuorips Inc. | -18.8% FY2025 | FY2025 |
| 56 | 4571 Nano Holdings, Inc. | -19.1% FY2025 | FY2025 |
| 57 | 4892 Cyfuse Biomedical K.K. | -19.6% FY2025 | FY2025 |
| 58 | 130A Veritas In Silico Inc. | -20.6% FY2025 | FY2025 |
| 59 | 206A PRISM BioLab Co.,LTD | -21.9% FY2024 | FY2024 |
| 60 | 4599 StemRIM Inc. | -23.2% FY2024 | FY2024 |
| 61 | 4891 TMS Co., Ltd. | -24.3% FY2025 (10 months) | FY2025 (10 months) |
| 62 | 4576 D.Western Therapeutics Institute, Inc. | -32.9% FY2025 | FY2025 |
| 63 | 4591 RIBOMIC Inc. | -37.2% FY2025 | FY2025 |
| 64 | 4896 K Pharma,Inc. | -37.5% FY2025 | FY2025 |
| 65 | 4884 Kringle Pharma, Inc. | -37.9% FY2024 | FY2024 |
| 66 | 4596 Kubota Pharmaceutical Holdings Co., Ltd. | -38.4% FY2025 | FY2025 |
| 67 | 4592 SanBio Company Limited | -40.3% FY2025 | FY2025 |
| 68 | 4882 Perseus Proteomics Inc. | -41.7% FY2025 | FY2025 |
| 69 | 4586 Medrx Co., Ltd. | -42.3% FY2025 | FY2025 |
| 70 | 4583 Chiome Bioscience Inc. | -46.8% FY2025 | FY2025 |
| 71 | 190A Chordia Therapeutics Inc. | -48.8% FY2024 | FY2024 |
| 72 | 4597 Solasia Pharma K.K. | -50.0% FY2025 | FY2025 |
| 73 | 4564 OncoTherapy Science, Inc. | -51.8% FY2025 | FY2025 |
| 74 | 4588 Oncolys BioPharma Inc. | -53.1% FY2025 | FY2025 |
| 75 | 4575 CanBas Co., Ltd. | -54.2% FY2025 | FY2025 |
| 76 | 4883 Modalis Therapeutics Corporation | -64.7% FY2025 | FY2025 |
| 77 | 520A J-Pharma Co.,Ltd. | -64.8% FY2025 | FY2025 |
| 78 | 4594 BrightPath Biotherapeutics Co., Ltd. | -70.1% FY2025 | FY2025 |
| 79 | 504A Innovacell Inc. | -72.0% FY2025 | FY2025 |
| 80 | 4881 FunPep Company Limited | -75.1% FY2025 | FY2025 |
| 81 | 4563 AnGes, Inc. | -101.7% FY2025 | FY2025 |
| 82 | 4582 SymBio Pharmaceuticals Limited | -108.1% FY2025 | FY2025 |
| 83 | 4572 Carna Biosciences, Inc. | -108.5% FY2025 | FY2025 |
| 84 | 4598 Delta-Fly Pharma, Inc. | -477.5% FY2025 | FY2025 |